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Histamine mobilization in response to local microinfusion of pituitary adenylate cyclase-activating peptide (PACAP) (horizontal line) in hypergastrinaemic rats (omeprazole pretreatment for 4 days) and hypogastrinaemic rats (food deprivation for 24 h). The high basal histamine concentrations in the microdialysate in the hypergastrinaemic rats can be ascribed to the high serum gastrin concentration (see text). Means±s.e.means (vertical lines) are shown; n=6.
