Figure 1.

2-APB and XeC does not inhibit caffeine-elicited cytosolic Ca²⁺ increases in canine PASMCs. (a) 10 mM caffeine (CAF) induced Ca²⁺ transients in the absence then the presence of 50 μM 2-APB. (b) Bars show the magnitude of the peak cytosolic Ca²⁺ increase elicited by 10 mM caffeine before and during 50 μM 2-APB. There was no significant difference between the two groups using a two-tailed paired t-test (n=9). (c) Bars show the magnitude of the peak cytosolic Ca²⁺ increase elicited by 10 mM caffeine before and during 20 μM XeC. There was no significant difference between the two groups using a two-tailed paired t-test (n=23). Bars represent means±s.e.m. 2-APB, 2-aminobiphenylborate; PASMCs, canine pulmonary arterial smooth muscle cells; XeC, xestospongin-C.