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. 2007 Jul 2;152(1):141–150. doi: 10.1038/sj.bjp.0707361

Figure 1.

Figure 1

Molecular structure of ARL 67156. The arrow indicates the potential cleavage site between the α- and β-phosphates of ARL 67156 by NPPs. The site of cleavage by NTPDases between the β- and γ-phosphate is blocked by −CBr2− and can therefore not be hydrolysed by these enzymes (Picher et al., 1996) as confirmed by HPLC (see Results). ARL 67156, 6-N,N-diethyl-D-β-γ-dibromomethylene adenosine triphosphate; NPP, nucleotide pyrophosphatase/phosphodiesterase; NTPDases, nucleoside triphosphate diphosphohydrolases; HPLC, high-performance liquid chromatography.