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Comparative effect of ARL 67156 on the biochemical activity of human NTPDases
| Enzyme | % of inhibition (100 μM substrate and 100 μM ARL 67156) |
||
|---|---|---|---|
| ATP (n=4–9) | ADP (n=3) | UTP (n=3) | |
| NTPDase1 | 48±5 | 70±4 | 89±2 |
| NTPDase2 | 15±5 | 1±6 | 25±6 |
| NTPDase3 | 42±5 | 69±3 | 73±3 |
| NTPDase8 | 20.1±0.4 | 21±4 | 38±1 |
Abbreviations: ARL 67156, 6-N,N-diethyl-D-β-γ-dibromomethylene adenosine triphosphate; NTPDase, nucleoside triphosphate diphosphohydrolase.
