| Enzyme |
Farnesyl transferase |
Kaminski et al. (1997) |
| |
Thrombin |
Srinivasen et al. (2002) |
| |
Acetylcholinesterase |
Sippl (2002), Rollinger et al. (2004)
|
| |
Protein-tyrosine-phosphatase 1B |
Doman et al. (2002), Sippl (2002)
|
| |
Factor-Xa |
O'Brien et al. (2005) |
| |
Ubiquitin isopeptidase |
Mullally et al. (2001), Mullally and Fitzpatrick (2002)
|
| |
Aromatase (CYP19) |
Schuster et al. (2006) |
| |
COX-1, COX-2 |
Rollinger et al. (2005) |
| |
LOX |
Charlier et al. (2006) |
| |
12-LOX and 15-LOX |
Kenyon et al. (2006) |
| |
Renin |
Van Drie (1993), Khadikar et al. (2005), Bursavich and Rich (2002), Krovat and Langer (2004), Hert et al. (2004)
|
| |
Cathepsin D |
Kick et al. (1997), Pegg et al. (2001), Huo et al. (2002), Ekins et al. (2004a)
|
| |
Glycogen phosphorylase |
Klabunde et al. (2005) |
| |
Sirtuin type 2 |
Tervo et al. (2004) |
| |
|
|
| Drug metabolizing enzymes |
Catechol O-methyltransferase |
Chen et al. (2005) |
| |
Cytochrome P450s |
de Groot and Ekins (2002b), de Graaf et al. (2005), de Groot (2006), Lill et al. (2006)
|
| |
UDP-glucuronosyltransferases |
Smith et al. (2004), Sorich et al. (2004)
|
| |
Sulfotransferases |
Dajani et al. (1999) |
| |
|
|
| Kinases |
Protein kinase C |
Wang et al. (1994) |
| |
CDK1 |
Furet et al. (2000), Kunick et al. (2005)
|
| |
Syk C-terminal SH2 domain |
Niimi et al. (2001) |
| |
EFGR tyrosine kinase |
Peng et al. (2003) |
| |
Lck SH2 domain |
Huang et al. (2004) |
| |
ERK2 |
Hancock et al. (2005) |
| |
BCR-ABL tyrosine kinase |
Wolber and Langer (2005) |
| |
CK2 and PKD |
Fullbeck et al. (2005) |
| |
|
|
| Transporter |
Na+/D-glucose co-transporter |
Wielert-Badt et al. (2000) |
| |
ADME-related (for example P-gp) |
Chang and Swaan (2005), Zhang et al. (2002a), Zhang et al. (2002b)
|
| |
|
|
| Receptor |
Endothelial differentiation gene receptor antagonists |
Koide et al. (2002) |
| |
Urotensin antagonists |
Flohr et al. (2002) |
| |
CCR5 antagonist |
Debnath (2003) |
| |
Oestrogen receptor |
Sippl (2002) |
| |
AMPA receptor |
Barreca et al. (2003) |
| |
5-HT2B
|
Singh and Kumar (2001), Brea et al. (2002), Manivet et al. (2002), Setola et al. (2005)
|
| |
5-HT1A
|
Hibert et al. (1988), Nowak et al. (2006), Becker et al. (2006)
|
| |
5-HT1D
|
Glen et al. (1995) |
| |
5-HT6
|
Hirst et al. (2003) |
| |
Na+, K+-ATPase |
Keenan et al. (2005) |
| |
Dopamine |
Oloff et al. (2005) |
|
α1A
|
Hessler et al. (2005)
|
| Channels |
Potassium, sodium and calcium |
Reviewed by Aronov et al. (2006)
|
| |
|
|
| Transcription factors |
AP-1 transcription factor |
Tsuchida et al. (2006) |
| |
|
|
| Other therapeutic targets |
Mesangial cell proliferation inhibitor |
Kurogi et al. (2001b) |
| |
Prion diseases |
Lorenzen et al. (2005) |
| |
Gβγ-protein–protein interaction |
Bonacci et al. (2006) |
| |
Integrin VLA-4 (α4β1) |
Singh et al. (2002b), Singh et al. (2002a)
|
| |
|
|
| Antibacterial |
Mycobacterium tuberculosis thymidine monophosphosphate kinase |
Gopalakrishnan et al. (2005) |
| |
|
|
| Antiviral |
HIV integrase |
Carlson et al. (2000), Nicklaus et al. (1997)
|
| |
HIV-1 reverse transcriptase |
Griffith et al. (2005), O'Brien et al. (2005)
|
| |
Neuroamidase |
Steindl and Langer (2004) |
| |
Human rhinovirus 3C protease |
Steindl et al. (2005a) |
| |
Human rhinovirus coat protein |
Steindl et al. (2005b) |
| |
Rhinovirus serotype 16 |
Wolber and Langer (2005) |
| |
SARS coronavirus 3C-like proteinase |
Liu et al. (2005) |
| |
Hepatitis C virus RNA-dependent RNA polymerase |
Di Santo et al. (2005) |
