Table 3.
Effect of treatment on liver, kidney, and urinary GAG levels
| Organ | Day post injection | Amount of injected virus | GAG* |
|---|---|---|---|
| Liver | Untreated control (−/−) | — | 2595 |
| 16 | 4.48 × 108 | 1389 | |
| 16 | 1.79 × 109 | 399 | |
| 35 | 4.48 × 108 | 336 | |
| 35 | 1.79 × 109 | 319 | |
| Heterozygote (+/−) | — | 821 | |
| Kidney | Untreated control (−/−) | — | 3585 |
| 16 | 4.48 × 108 | 3601 | |
| 16 | 1.79 × 109 | 2363 | |
| 35 | 4.48 × 108 | 2517 | |
| 35 | 1.79 × 109 | 2243 | |
| Heterozygote (+/−) | — | 652 | |
| Urine* | Untreated control (−/−; n = 2) | 1674, 758 | |
| 35 | 4.48 × 108 | 488 | |
| 35 | 1.79 × 109 | 469 | |
| Untreated +/+ normal | — | 163 | |
| Untreated +/− | — | 63 |
*
Urinary GAG is expressed in μg/mg creatinine; GAG levels in liver and kidney are expressed in μg/mg protein.