Table 3.
Subjective Results from Post-Sleep Questionnaire
| Placebo | Ramelteon 8 mg* | Ramelteon 16 mg* | |
|---|---|---|---|
| sSL (min) | |||
| Baseline | 77.0 (3.7) | 78.5 (3.7) | 75.2 (3.8) |
| Week 1 | 70.2 (3.8) | 52.9 (3.7) | 56.3 (3.9) |
| (p <0.001) | (p = 0.009) | ||
| Week 3 | 65.7 (3.9) | 47.2 (3.8) | 54.3 (3.9) |
| (p <0.001) | (p = 0.034) | ||
| Week 5 | 61.5 (3.7) | 44.8 (3.6) | 53.8 (3.8) |
| (p = 0.001) | (p = 0.134) | ||
| Run-out | 54.9 (4.7) | 53.6 (4.6) | 55.1 (4.6) |
| sTST (min) | |||
| Baseline | 311.6 (5.5) | 325.1 (5.4) | 313.2 (5.5) |
| Week 1 | 329.6 (5.5) | 353.8 (5.4) | 352.0 (5.6) |
| (p = 0.001) | (p = 0.003) | ||
| Week 3 | 340.1 (5.4) | 360.3 (5.4) | 349.7 (5.5) |
| (p = 0.006) | (p = 0.197) | ||
| Week 5 | 347.1 (5.7) | 365.4 (5.6) | 358.9 (5.7) |
| (p = 0.018) | (p = 0.132) | ||
| Run-out | 359.7 (6.4) | 363.8 (6.4) | 365.0 (6.4) |
| Sleep quality | |||
| Baseline | 4.2 (0.07) | 4.1 (0.07) | 4.3 (0.07) |
| Week 1 | 3.9 (0.05) | 3.8 (0.05) | 3.8 (0.05) |
| Week 3 | 3.7 (0.06) | 3.7 (0.06) | 3.7 (0.06) |
| Week 5 | 3.7 (0.06) | 3.6 (0.06) | 3.6 (0.06) |
| Run-out | 3.6 (0.08) | 3.6 (0.08) | 3.5 (0.08) |
| Awake time (min) | |||
| Baseline | 99.9 (5.65) | 86.3 (5.52) | 93.4 (5.69) |
| Week 1 | 86.1 (4.54) | 72.3 (4.46) | 67.8 (4.63) |
| (p = 0.026) | (p = 0.004) | ||
| Week 3 | 69.2 (4.68) | 72.2 (4.58) | 74.1 (4.70) |
| Week 5 | 71.2 (4.80) | 70.3 (4.70) | 68.0 (4.82) |
| Run-out | 64.8 (4.78) | 60.8 (4.72) | 58.6 (4.73) |
sSL = subjective sleep onset, sTST = subjective total sleep time
Values represent least-squares mean (with standard error).
*
p values for ramelteon vs placebo.