Table 5.
Next-Day Residual Effects
| Placebo | Ramelteon 8 mg* | Ramelteon 16 mg* | |
|---|---|---|---|
| DSST | |||
| Baseline | 43.8 (1.12) | 45.2 (1.10) | 44.0 (1.12) |
| Week 1 | 43.9 (0.59) | 43.8 (0.58) | 43.5 (0.59) |
| Week 3 | 45.0 (0.67) | 44.9 (0.67) | 44.8 (0.66) |
| Week 5 | 46.1 (0.74) | 46.8 (0.75) | 46.4 (0.73) |
| Memory Recall Test (immediate) | |||
| Baseline | 7.6 (0.19) | 7.5 (0.19) | 7.5 (0.19) |
| Week 1 | 7.7 (0.17) | 7.3 (0.17) | 7.6 (0.17) |
| Week 3 | 8.2 (0.17) | 7.5 (0.17) | 8.1 (0.17) |
| (p = 0.005) | (p = 0.594) | ||
| Week 5 | 8.1 (0.18) | 7.7 (.018) | 8.3 (0.18) |
| Memory Recall Test (delayed) | |||
| Week 1 | 4.2 (0.16) | 3.6 (0.15) | 3.8 (0.16) |
| (p = 0.004) | (p = 0.057) | ||
| Week 3 | 5.5 (0.22) | 5.4 (0.22) | 5.6 (0.21) |
| Week 5 | 4.5 (0.19) | 4.1 (0.19) | 4.4 (0.19) |
| Level of Alertness | |||
| Baseline | 3.8 (0.08) | 3.8 (0.08) | 3.6 (0.08) |
| Week 1 | 3.8 (0.07) | 3.7 (0.07) | 3.9 (0.07) |
| Week 3 | 3.7 (0.07) | 3.6 (0.07) | 3.7 (0.07) |
| Week 5 | 3.7 (0.07) | 3.5 (0.07) | 3.6 (0.07) |
| (p = 0.034) | (p = 0.308) | ||
| Ability to Concentrate | |||
| Baseline | 3.7 (0.08) | 3.8 (0.08) | 3.6 (0.08) |
| Week1 | 3.9 (0.07) | 3.7 (0.07) | 3.9 (0.07) |
| (p = 0.031) | (p = 0.957) | ||
| Week 3 | 3.7 (0.07) | 3.6 (0.07) | 3.6 (0.07) |
| Week 5 | 3.7 (0.07) | 3.6 (0.07) | 3.6 (0.07) |
Note: Values represent least-squares mean (SE). For the DSST and memory recall tests, a higher score is better. For level of alertness and ability to concentrate, a lower score is better.
*
p values for ramelteon vs placebo.