Figure 5.

Mean (SEM) plasma high-sensitivity C-reactive protein (CRP) in n = 4 subjects undergoing 10 consecutive nights of sleep restricted to 4.2 h time in bed, and in n = 5 control subjects who had 10 consecutive nights of sleep restricted to 8.2 h time in bed (closed squares). Significance of difference in change from baseline to day 10 between groups (p = 0.08 for interaction) by mixed-models analysis of variance on log-transformed data: the change from baseline to day 10 for the 4-h sleep restriction group was significant (p = 0.05), whereas the change from baseline to day 10 in the 8-h control group was not (p = 0.72). Figure adapted from Meier-Ewert et al.⁷¹