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. Author manuscript; available in PMC: 2008 Apr 15.
Published in final edited form as: Arch Biochem Biophys. 2006 Dec 3;460(2):262–273. doi: 10.1016/j.abb.2006.11.018

Figure 1.

Figure 1

A 2C5/BM-3 hybrid homology-model based representation of 1,25(OH)2D3 bound in the rat CYP24A1 active-site.

Calcitriol is seen docked in the rat CYP24A1 active site with the proximity of putative binding residues (M246, F249, V391, T394 and I500) shown. Also shown are influential residues from the A' (W75) and A-helices (Y89), and the conserved catalytic threonine (T330) in the I-helix. The K'-helix residue Thr-416, not studied in the current work is also shown. Thr-416 along with Ile-500, have been reported to influence the catalytic regiospecificity of rat CYP24A1 [20]. Image was generated using VMD [22] .