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. 2007 Sep 20;117(10):2983–2992. doi: 10.1172/JCI30485

Figure 7. Peritoneal macrophages from CEH-transgenic mice have lower EC content.

Figure 7

Thioglycollate-elicited peritoneal macrophages from chow-fed mice were isolated and loaded with AcLDL. After a 24-hour equilibration period, 1 set was incubated in serum-free medium (no extracellular acceptor) or in medium containing 10% FBS as the extracellular acceptor. Lipids were extracted after 24 hours and cellular FC and EC levels determined and normalized to cellular protein. Data are expressed as mean ± SD; n = 3. The percent decrease in FC and EC in the presence of extracellular acceptor is significantly higher in macrophages from Ldlr–/–CEHTg mice (*P = 0.05 and **P = 0.048) compared with the corresponding decrease in macrophages from Ldlr–/– mice.