Figure 6. Both IL-12 and IL-13Rα2 regulate AHR and goblet cell hyperplasia in the absence of IL-10.

Animals were sensitized and challenged as in Figure 1. *P < 0.05, 1-way ANOVA. (A) Five-micrometer sections were cut from paraffin-embedded lung tissue and stained with alcian blue–PAS. Five lungs from each group were scored in a blinded fashion. (B) AHR. Penh measurements 24 hours after the final airway challenge using a Buxco system with mice exposed to increasing doses of methacholine. Results from 1 of 2 representative experiments are shown.