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. 2007 Sep 20;117(11):3475–3488. doi: 10.1172/JCI31743

Figure 3. Effects of CNS-Mcr on WAT.

Figure 3

(A) Effect of a 7-day i.c.v. SHU9119 (24 nmol/d) and MTII (1 nmol/d) infusion on epididymal WAT mRNA expression of FAS, SCD-1, LPL, ACCα, CPT-1a, INSIG2, hormone-sensitive lipase (HSL), and adipose TAG lipase (ATGL). Effect of a 7-day i.c.v. SHU9119 (24 nmol/d) and MTII (1 nmol/d) infusion on epididymal WAT FAS activity (B) and FAS protein expression (C). (D) Effect of a 48-hour i.c.v. SHU9119 (24 nmol/d) and MTII (1 nmol/d) infusion on epididymal WAT mRNA expression of FAS, SCD1, LPL, ACCα, CPT-1a, INSIG2, HSL, and ATGL. Data are presented as values normalized to the housekeeping gene RPS29. mRNA levels are relative to controls. Values are mean ± SEM of 7–8 animals per group. ***P < 0.001, **P < 0.01 versus controls; #P < 0.05 MTII versus saline-pf; *P < 0.05.