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. 2007 Sep 20;117(11):3475–3488. doi: 10.1172/JCI31743

Figure 8. Schematic overview summarizing the physiological effects of CNS-Mcr blockade on peripheral tissues.

Figure 8

Blockade of CNS-Mcr decreases thermogenesis and glucose utilization in BAT; decreases glucose utilization in muscle; increases TAG content, lipoprotein assembly, and secretion in liver; and increases TAG synthesis and uptake as well as glucose uptake and insulin sensitivity in fat tissue. Combined, these parallel metabolic changes in multiple tissues represent a synergistic shift in substrate choice and nutrient partitioning, resulting in increased energy storage.