Figure 4.

Effects of SNP and ET-1 on gel contraction. (a) Gels containing BASMCs or TGFβ₁-treated BAECs were contracted with 10 μM ATP, and the effects of sequential application of 10 nM and 1 μM SNP were examined (closed symbols, n=4–6). Control data were obtained without SNP application from the same gel preparation (open symbols, n=4–6). Note that 10 nM SNP induced relaxation only in gels containing BASMCs. (b) ET-1 (1 nM) induced contraction in gels with BASMCs, but not in gels containing control or TGFβ₁-treated BAECs (n=4–6).