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Chemical structures and mechanism of MB07811 conversion to MB07344. (A) Chemical structure of KB-141. (B) Chemical structures of MB07811 and the products generated from the CYP3A-catalyzed cleavage reaction, namely MB07344 and the glutathione conjugate (2) produced from the addition of glutathione (GSH) to the aryl vinyl ketone byproduct. Ar, 3-chlorophenyl.
