Fig. 2.
MB07811 metabolism, excretion, and tissue distribution. (A) Mean (±½ range) intracellular levels (circles) and levels in culture medium (triangles) of MB07344 from isolated, cultured rat hepatocytes incubated with 10 μM MB07811 (open symbols, n = 2) or 10 μM MB07344 (filled symbols, n = 2). (B) Mean (± SEM) systemic (filled circles, n = 5) and portal vein (open circles, n = 4) plasma concentrations of MB07811 after an oral dose of MB07811 (3 mg/kg) to male SD rats; (C) Mean (± SEM) MB07344 levels in bile samples collected over the indicated periods from bile duct-cannulated male SD rats (n = 3) treated with MB07344 (10 mg/kg, i.v.). (D) Approximate mean tissue concentration (total radioactivity) for the tissues with the highest concentration 3 and 24 h after an oral dose of [14C]-MB07811 (5 mg/kg) to male SD rats (n = 4). Tissues evaluated (liver, spleen, lymph, thyroid, testes, fat, bladder, prostate, pancreas, stomach, small and large intestine, adrenals, kidneys, thymus, heart, bone marrow, muscle, eye, brain, pituitary, skin, lung, and bone) but not listed in the figure (other than stomach and intestine) have <5% of the liver concentration at 3 h and <3% at 24 h.