Fig. 4.
Effects on SD rat cardiac function and THA. (A and B) Dose–response of T3 (▴, 6.5–650 μg·kg−1·day−1), KB-141 (○, 0.01–5 mg·kg−1·day−1), and MB07811 (□, 0.1–50 mg·kg−1·day−1) on heart rate (A) and LV dP/dt (B) in SD rats (n = 3–6 per dose) treated for 7 days. (C–E) Effects of KB-141 and MB07811 on total and free T4 (C), total and free T3 (D), and plasma TSH and pituitary TSHβ mRNA (E) (relative units) in SD rats (n = 5–6 per group) treated once daily for 28 days with vehicle (black bars), KB-141 at 0.1 mg/kg (white bars) and 1 mg/kg (white hatched bars), and MB07811 at 3 mg/kg (gray bars) and 30 mg/kg (gray hatched bars). The low and high doses for KB-141 are equivalent to 2× and 20×, respectively, the CF rat ED50. The doses for MB07811 are equivalent to 7.5× and 75× the CF rat ED50. *, P < 0.05.