Table 1.

Databases used. Summary of databases mentioned in this analysis

Database	Description	nsSNPs used for this study	Availability
dbSNP	Database of Single Nucleotide Polymorphisms	21471	[8]
OMIM	Online database of Mendelian Inherited dimorphisms in Man	2256	[15]
HapMap	Database quantifying frequencies of common haplotypes in four populations	5770	[3]
HGMD	Human Gene Mutation Database of mutations within the coding regions, splicing and regulatory regions of human genes causing inherited disease	N/A	[12]
GAD	Genetic association database of medically relevant polymorphisms identified in published scientific papers	N/A	[13]
HGVBase	Human Genome Variation Database	N/A	[6]
LS-SNP	Database of large scale annotation of predicted effects of human SNPs.	11220	[24]
Polyphen	Database of predicted functional effect of human nsSNPs	4459	[27]
HOMSTRAD	Database of protein structures classified by protein family	N/A	[40]