Figure 3.

Effect of the matrilysin null mutation on tumor multiplicity and diameter in Min/+ animals. Min/+; mmp7−/− N₅F₁ (>96% C57BL/6) mice were generated as described in Materials and Methods. These mice were analyzed in comparison to Min/+ animals for tumor number (A) and diameter (B). The mean and median numbers of tumors for Min/+ were 25.4 and 24 (range = 20–38, n = 14), respectively, and for Min/+; mmp7−/−, the numbers were 10.5 and 11 (range = 7 to 12, n = 6), respectively (P < 0.0006). The mean diameters of tumors per mouse for Min/+ and Min/+; mmp7−/− were 2.0 and 1.6 mm, respectively (P < 0.003). The nonparametric Wilcoxon Rank Sum test was used to analyze the statistical significance of all data.