AAV and retroviral vectors. Arrows indicate promoters, open boxes indicate coding regions, and filled boxes indicate noncoding regions. TR, AAV terminal repeat; MLV, Moloney murine leukemia virus long terminal repeat; AP, alkaline phosphatase; neo, neomycin phosphotransferase; pA, polyadenylylation signal; RSV, Rous sarcoma virus long terminal repeat; hFIX, human FIX. The sequences between the AP coding region and the simian virus 40 promoter in AAV-LAPSN and CWRAPSP are 3′ untranslated sequences from the AP cDNA.