Figure 3.
Plasma levels of hFIX in mice after exposure to γ-irradiation and injection of AAV vectors. Negative-control mice ○ received 17 Gy of irradiation and 5 × 105 ffu of CWRAPSP by tail vein injection. Two mice received 1 × 106 cfu of the AAV-LIXSN vector by tail vein or direct injection and 17 Gy of irradiation (direct injection = ▪ and tail vein injection = ♦), two mice received 3 × 105 cfu of the AAV-LIXSN vector by direct injection and 18 Gy of irradiation (X and ∗), and two mice received approximately 2 × 109 particles of CWRIXSP by tail vein injection and 17 Gy irradiation (▴ and •).