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Effect of IL-6 on hepatocyte DNA synthesis in TNFR-I knockout mice (TNFR-I KO). Wild-type (WT) and TNFR-I mice were partially hepatectomized and killed 40 h after the operation. Three TNFR-I knockout animals and three wild-type mice received an s.c. injection of recombinant human IL-6 (1 mg/kg) 30 min before PH. All mice were injected with BrdUrd (BrdU) 2 h before killing (see Fig. 4). The ordinate shows the percentage of hepatocytes labeled by BrdUrd.
