Figure 7.

Effect of IL-6 on transcription factor binding in TNFR-I knockout mice. Wild-type and TNFR-I mice were partially hepatectomized and killed 3 h after PH. A group of knockout mice received an s.c. injection of IL-6 (see Fig. 5). Nuclear extracts (prepared from two animals in each group) were analyzed by EMSA as described in Fig. 1 (10 μg/lane). Lanes: 1, wild-type mice; 2, TNFR-I knockout mice; and 3, TNFR-I knockout mice injected with IL-6. The arrow on the right indicates the position of the STAT3 band.