Figure 3.

Behavioral analysis. Performance of adult (7-month-old; A and B) and young adult (6-week-old; C) mice walking over a 1-m-long, 2-cm-wide runway. Four sessions on consecutive days are documented in A and B; the day 1 and 2 sessions after which no further changes were observed are shown in C. (A) Average number of slips counted on one side. (B) Percentage of drops during passage. In case of no drops, the value 0 is given at the position of the bar in A. Except for 129Sv mice (mean ± range), values are the means ± SEM. (D) Performance of 2-month-old males in the thin horizontal stationary rod test. The time spent on the rod up to a limit of 60 sec was measured. Values are the means ± SEM. ∗, P < 0.05; ∗∗, P < 0.005 compared with wild-type mice.