Figure 1.

Performance of GFAP-IL6 transgenic mice in a discriminated avoidance learning task. (a) Correct avoidances (mean ± SE) on acquisition (3 months of age) and subsequent retests at 6 and 12 months of age for nontransgenic (+/+) (n = 8), heterozygous GFAP-IL6 (+/tg) (n = 10), and homozygous GFAP-IL6 (tg/tg) mice (n = 7). Homozygous mice were significantly different from controls throughout the study and heterozygous mice tested at 3 and months of age. (b) Errors (mean ± SE) on acquisition and subsequent retests for nontransgenic and transgenic mice. (c) Escape latency (mean ± SE) on acquisition and subsequent retests for nontransgenic and transgenic mice.