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. 1997 Feb 18;94(4):1506–1511. doi: 10.1073/pnas.94.4.1506

Figure 3.

Figure 3

Modulation of NE secretion by adrenergic receptors. (A) Amperometric recordings in Ringer’s (Control), in Ringer’s with 2 μM UK-14,304 (UK), and in Ringer’s solution again (Wash out). The application of UK-14,304 started 15 s before stimuli and continued during the recording. (B) Overnight incubation with 500 ng/ml PTX reduced the inhibition of NE secretion by UK-14,304. PTX was removed before the measurement. (C) Reduction of secretion by agents acting on adrenergic receptor pathways. NE secretion relative to controls was measured with 2 μM UK-14,304 alone (37.7 ± 5.3%) (n = 7), 2 μM UK-14,304 plus 10 μM yohimbine (76.0 ± 12.1%) (n = 3), 2 μM UK-14,304 after PTX treatment (77.0 ± 3.5%) (n = 5), 10 μM phenylephrine (79.6 ± 3.5%) (n = 5), 10 μM isoproterenol (105 ± 14.6%) (n = 5), and 10 μM NE (50.3 ± 5.6%) (n = 3).