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. 1997 Feb 18;94(4):1506–1511. doi: 10.1073/pnas.94.4.1506

Figure 4.

Figure 4

Modulation of NE secretion by muscarinic receptors. (A) Amperometric recordings in Ringer’s (Control), in Ringer’s with 10 μM Oxo-M (Oxo-M), and in Ringer’s solution again (Wash out). The application of Oxo-M started 15 s before stimuli and continued during the recording. (B) Overnight incubation with 500 ng/ml PTX eliminates the inhibition of NE secretion by Oxo-M. PTX was absent during the measurement. (C) Reduction of secretion by agents acting on muscarinic receptor pathways. NE secretion relative to controls was measured with Oxo-M (37.0 ± 4.3%) (n = 13), Oxo-M after PTX treatment (92.3 ± 6.0%) (n = 4), Oxo-M plus pirenzepine (48.2 ± 4.3%) (n = 6), Oxo-M plus methoctramine (78.9 ± 6.7%) (n = 7), and Oxo-M plus tropicamide (87.2 ± 3.8%) (n = 5). Concentration of all agents was 10 μM except for PTX.