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. 1969 Mar 29;1(5647):812–815. doi: 10.1136/bmj.1.5647.812

Treatment of pulmonary embolism with streptokinase. A preliminary report

G A H Miller, R V Gibson, M Honey, G C Sutton
PMCID: PMC1982486  PMID: 5774078

Abstract

Nine patients with arteriographically proved pulmonary embolism have been treated by a 36-hour infusion of streptokinase. Satisfactory haemodynamic and arteriographic resolution was obtained in four patients with acute massive pulmonary embolism and in two with recent minor embolism. Little or no haemodynamic or arteriographic improvement was obtained in three patients with pulmonary thromboembolic disease of longer duration.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ALLISON P. R., DUNNILL M. S., MARSHALL R. Pulmonary embolism. Thorax. 1960 Dec;15:273–283. doi: 10.1136/thx.15.4.273. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. BARRITT D. W., JORDAN S. C. Anticoagulant drugs in the treatment of pulmonary embolism. A controlled trial. Lancet. 1960 Jun 18;1(7138):1309–1312. doi: 10.1016/s0140-6736(60)92299-6. [DOI] [PubMed] [Google Scholar]
  3. BROWSE N. L., JAMES D. C. STREPTOKINASE AND PULMONARY EMBOLISM. Lancet. 1964 Nov 14;2(7368):1039–1043. doi: 10.1016/s0140-6736(64)90991-2. [DOI] [PubMed] [Google Scholar]
  4. COTTON L. T., FLUTE P. T., TSAPOGAS M. J. Popliteal artery thrombosis treated with streptokinase. Lancet. 1962 Nov 24;2(7265):1081–1083. doi: 10.1016/s0140-6736(62)90786-9. [DOI] [PubMed] [Google Scholar]
  5. Dickie K., de Groot W. Urokinase in pulmonary thromboembolic disease: a preliminary report. Tex Rep Biol Med. 1967 Winter;25(4):613–624. [PubMed] [Google Scholar]
  6. Fred H. L., Axelrad M. A., Lewis J. M., Alexander J. K. Rapid resolution of pulmonary thromboemboli in man. An angiographic study. JAMA. 1966 Jun 27;196(13):1137–1139. [PubMed] [Google Scholar]
  7. GOODWIN J. F., HARRISON C. V., WILCKEN D. E. Obliterative pulmonary hypertension and thrombo-embolism. Br Med J. 1963 Mar 16;1(5332):701–contd. doi: 10.1136/bmj.1.5332.701. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. GORHAM L. W. A study of pulmonary embolism. I. A clinicopathological investigation of 100 cases of massive embolism of the pulmonary artery; diagosis by physical signs and differentiation from acute myocardial infarction. Arch Intern Med. 1961 Jul;108:8–22. doi: 10.1001/archinte.1961.03620070010003. [DOI] [PubMed] [Google Scholar]
  9. Hirsh J., Hale G. S., McDonald I. G., McCarthy R. A., Cade J. F. Resolution of acute massive pulmonary embolism after pulmonary arterial infusion of streptokinase. Lancet. 1967 Sep 16;2(7516):593–597. doi: 10.1016/s0140-6736(67)90741-6. [DOI] [PubMed] [Google Scholar]
  10. Hirsh J., Hale G. S., McDonald I. G., McCarthy R. A., Pitt A. Streptokinase therapy in acute major pulmonary embolism: effectiveness and problems. Br Med J. 1968 Dec 21;4(5633):729–734. doi: 10.1136/bmj.4.5633.729. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Thomas D. P. Treatment of pulmonary embolic disease. A critical review of some aspects of current therapy. N Engl J Med. 1965 Oct 21;273(17):885–892. doi: 10.1056/NEJM196510212731701. [DOI] [PubMed] [Google Scholar]
  12. Tow D. E., Wagner H. N., Jr Recovery of pulmonary arterial blood flow in patients with pulmonary embolism. N Engl J Med. 1967 May 11;276(19):1053–1059. doi: 10.1056/NEJM196705112761902. [DOI] [PubMed] [Google Scholar]

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