Table 1.
Genotypes of F2 mice
| Strain | +/+ (%) | +/− (%) | −/− (%) | Total |
|---|---|---|---|---|
| Mixed 129SvEMS × C57BL/6 | 21 (30.9) | 35 (51.5) | 12 (17.6) | 68 |
| Pure 129SvEMS | 6 (18.2) | 22 (66.7) | 5 (15.2) | 33 |
| Overall | 27 (26.7) | 57 (56.4) | 17 (16.8) | 101 |
The ratios of wild-type to heterozygous to homozygous mutants obtained from crosses between F1 animals of 129SvEMS origin or F1 hybrids of mixed background (129SvEMS × C57BL/6) were not significantly different from the expected 1:2:1, indicating that Kv3.1 expression is not required for embryonic development (χ2 = 3.65; P > 0.1).