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Age-dependent changes in brain Aβ and APP levels in the PDAPP transgenic mice. PDAPP mice were sacrificed at the ages indicated and levels of Aβ (A), APP-β (B), and APP-α/FL (C) were determined in the cortex (⋄), hippocampus (○), and cerebellum (▪) by ELISA. Values represent the means ± SD of 9–14 animals.
