Figure 4.

Age-dependent increases in Aβ plaque burden in the PDAPP mouse. Aβ deposits in the opposite hemisphere of brains used for Aβ and APP ELISAs at 4 (A, arrow indicates deposit), 8 (B), 10 (C), 12 (D), 16 (E), and 18 (F) months of age. Brains are shown from mice with Aβ ELISA values that correspond to the mean of their age group. Deposition typically occurs in an age- and region-dependent manner, with early and heavy involvement of the frontal cortex (F) and hippocampus (H), while the underlying thalamus (T) is devoid of plaques. Arrows in D outline the outer molecular layer of the dentate gyrus, which contains terminals from the perforant pathway. [Bar (in F) = 500 μm.]