Table 1.

Measured, fitted, and predicted parameters characterizing CP transport across human SC in vivo, after application of an aqueous CP solution for 15 and 60 min

Subject	[CP] in SC at 15 min,* M					[CP] in SC at 60 min,* M	60-min fitted parameters				60-min predicted parameters
		K†	D/L2,† 105 s−1	Cx=0,‡ M	tlag,§ min		K¶	Cx=0,‡ M	Jss,‖ nmol· cm−2·s−1	107 Kp,** cm·s−1	Jss,‡‡ nmol· cm−2·s−1	107Kp,†† cm·s−1
A	0.40	7.3	9.9	1.43	28.1	0.40	4.9	0.95	0.14	7.1	0.21	10.7
B	0.33	5.5	9.3	1.07	29.9	0.61	7.1	1.40	0.20	10.2	0.15	7.7
C	0.61	12.4	7.0	2.42	39.7	0.87	10.1	1.98	0.21	10.7	0.25	12.8
Mean	0.45	8.4	8.4	1.64	32.5	0.63	7.4	1.44	0.18	9.4	0.20	10.4
SD	0.15	3.6	1.5	0.70	6.2	0.24	2.6	0.52	0.04	1.9	0.05	2.6

^*Measured experimentally. 

^†From the fit of Eq. 1 to the 15-min in vivo data. 

^‡C_x=0 = K·C_veh. 

^§t_lag = L²/6D. 

^¶From the fit of the steady-state form of Eq. 1 to the 60-min in vivo data. 

^‖Calculated from the gradient of the fitted in vivo data to the steady-state form of Eq. 1, assuming L = 15 μm. 

^**K_p = J_ss/C_veh. 

^‡‡J_ss = (K·D/L)·C_veh using K and D/L² values from the 15-min exposure experiments, and assuming L = 15 μm. 

^††K_p = K·D/L using K and D/L² values from the 15-min exposure experiments, and assuming L = 15 μm.