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. 1969 May 3;2(5652):281–283. doi: 10.1136/bmj.2.5652.281

Placental Barrier to Coagulation Factors: Its Relevance to the Coagulation Defect at Birth and to Haemorrhage in the Newborn

J F Cade, J Hirsh, M Martin
PMCID: PMC1983203  PMID: 5780455

Abstract

The placental barrier to coagulation factors was assessed by measuring their levels in maternal venous and neonatal umbilical arterial and venous blood and was found to be largely complete. Detailed coagulation assessments in a large number of term and premature neonates showed that term neonates had a mild coagulation deficiency at birth. Premature neonates had a more definite deficiency, which became more severe with increasing prematurity. Mortality in low birth weight premature infants was associated with a severe coagulation deficiency, and was frequently due to cerebral haemorrhage. It is suggested that the coagulation system of low birth weight infants should be assessed to enable prophylactic treatment of those with a severe deficiency.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ABALLI A. J., DE LAMERENS S. Coagulation changes in the neonatal period and in early infancy. Pediatr Clin North Am. 1962 Aug;9:785–817. doi: 10.1016/s0031-3955(16)31311-6. [DOI] [PubMed] [Google Scholar]
  2. ALEXANDER B., MEYERS L., KENNY J., GOLDSTEIN R., GUREWICH V., GRINSPOON L. Blood coagulation in pregnancy: proconvertin and prothrombin, and the hypercoagulable state. N Engl J Med. 1956 Feb 23;254(8):358–363. doi: 10.1056/NEJM195602232540803. [DOI] [PubMed] [Google Scholar]
  3. BRETON A., GOUDEMAND M., HUTIN A., CAUDRELIER J. R., GAUDIER B. [Study of blood coagulability in the premature newborn infant]. Arch Fr Pediatr. 1960;17:143–163. [PubMed] [Google Scholar]
  4. FRESH J. W., FERGUSON J. H., LEWIS J. H. Blood-clotting studies in parturient women and the newborn. Obstet Gynecol. 1956 Feb;7(2):117–127. [PubMed] [Google Scholar]
  5. Gilliland M. J. Thrombophlebitis and embolic phenomena in pregnancy. Relationship to the clotting mechanism. Presented as a seminar sponsored by The Faculty of the Mayo Graduate School of Medicine. Minn Med. 1966 Oct;49(10):1597–1602. [PubMed] [Google Scholar]
  6. Gray O. P., Ackerman A., Fraser A. J. Intracranial haemorrhage and clotting defects in low-birth-weight infants. Lancet. 1968 Mar 16;1(7542):545–548. doi: 10.1016/s0140-6736(68)92827-4. [DOI] [PubMed] [Google Scholar]
  7. Hirsh J., Buchanan J. G., De Gruchy G. C., Baikie A. G. Hypofibrinogenaemia without increased fibrinolysis in leukaemia. Lancet. 1967 Feb 25;1(7487):418–420. doi: 10.1016/s0140-6736(67)91178-6. [DOI] [PubMed] [Google Scholar]
  8. KASPER C. K., HOAG M. S., AGGELER P. M., STONE S. BLOOD CLOTTING FACTORS IN PREGNANCY: FACTOR 8 CONCENTRATIONS IN NORMAL AND AHF-DEFICIENT WOMEN. Obstet Gynecol. 1964 Aug;24:242–247. [PubMed] [Google Scholar]
  9. Kerr C. B., Preston A. E., Barr A., Biggs R. Further studies on the inheritance of factor 8. Br J Haematol. 1966 Mar;12(2):212–233. doi: 10.1111/j.1365-2141.1966.tb05627.x. [DOI] [PubMed] [Google Scholar]
  10. Markarian M., Lindley A., Jackson J. J., Bannon A. Coagulation factors in pregnant women and premature infants with and without the respiratory distress syndrome. Thromb Diath Haemorrh. 1967 May 31;17(3-4):585–594. [PubMed] [Google Scholar]
  11. PRESTON A. E. THE PLASMA CONCENTRATION OF FACTOR VIII IN THE NORMAL POPULATION. I. MOTHERS AND BABIES AT BIRTH. Br J Haematol. 1964 Jan;10:110–114. doi: 10.1111/j.1365-2141.1964.tb00683.x. [DOI] [PubMed] [Google Scholar]
  12. TALBERT L. M., LANGDELL R. D. NORMAL VALUES OF CERTAIN FACTORS IN THE BLOOD CLOTTING MECHANISM IN PREGNANCY. Am J Obstet Gynecol. 1964 Sep 1;90:44–50. doi: 10.1016/s0002-9378(16)34890-6. [DOI] [PubMed] [Google Scholar]

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