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Mechanism of control of PLD activity by GnRH receptors. APs, action potentials; PC, phosphatidylcholine; and AA, arachidonic acid. The PA formed during hydrolysis of PC by PLD and the DAG produced during PLC-mediated hydrolysis of PIP2 are interconverted by the actions of DAG-kinase and PA-phosphohydrolase. Ethanol impairs the formation of PA at concentrations of 50–300 mM, and micromolar concentrations of propranolol inhibit the activity of PA-phosphohydrolase.
