Skip to main content
. Author manuscript; available in PMC: 2007 Sep 19.
Published in final edited form as: Science. 2006 Jun 22;313(5785):324–328. doi: 10.1126/science.1129462

Fig. 4.

Fig. 4

αSyn-induced cyto-toxicity and vesicular trafficking defects are modified by ER-Golgi trafficking components. The trafficking of CPY in cells expressing αSyn-WTand harboring either galactose-inducible GYP8 (A and B), galactose-inducible YPT1 (A and B), or SLY1-20 (C and D) was monitored by radio-labeling after 7 hours (C and D) or 8 hours (A and B) of induction and compared to trafficking in control cells (Vector). (B and D) Graphic representation of the amount of CPY remaining in the ER [p1/(p1 + p2 + mCPY)]. (E) Cells expressing αSyn-WT–GFP (green fluorescence protein) and HA (hemagglutin)–Ypt1p were examined by fluorescence and indirect immunofluorescence microscopy after 6 hours of αSyn induction.