Abstract
Patients with cirrhosis were found to be extremely sensitive to chlorpromazine as shown by slowing of the electroencephalograph (E.E.G.), which was particularly definite in those who had had hepatic encephalopathy previously. Patients showing the most definite E.E.G. changes were in general very sleepy and took some hours to recover after taking chlorpromazine. It is concluded that phenothiazine drugs should be used very cautiously in patients with alcoholic liver disease.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- FIGURELLI F. A. Delirium tremens; reduction of mortality and morbidity with promazine. J Am Med Assoc. 1958 Feb 15;166(7):747–750. doi: 10.1001/jama.1958.02990070033008. [DOI] [PubMed] [Google Scholar]
- GODFREY L., KISSEN M. D., DOWNS T. M. Treatment of the acute alcohol-withdrawal syndrome. Q J Stud Alcohol. 1958 Mar;19(1):118–124. [PubMed] [Google Scholar]
- LAIDLAW J., READ A. E., SHERLOCK S. Morphine tolerance in hepatic cirrhosis. Gastroenterology. 1961 Mar;40:389–396. [PubMed] [Google Scholar]
- LEACH H., CRIMMIN W. R. The colorimetric estimation of 3-chlorpromazine in biological fluids. J Clin Pathol. 1956 May;9(2):164–165. doi: 10.1136/jcp.9.2.164. [DOI] [PMC free article] [PubMed] [Google Scholar]
- READ A. E., LAIDLAW J., HASLAM R. M., SHERLOCK S. Neuropsychiatric complications following chlorothiazide therapy in patients with hepatic cirrhosis: possible relation to hypokalaemia. Clin Sci. 1959 Aug;18:409–423. [PubMed] [Google Scholar]
- READ A. E., LAIDLAW J., SHERLOCK S. Neuropsychiatric complications of portacaval anastomosis. Lancet. 1961 May 6;1(7184):961–963. doi: 10.1016/s0140-6736(61)91880-3. [DOI] [PubMed] [Google Scholar]
- SELIGSON D., HIRAHARA K. The measurement of ammonia in whole blood, erythrocytes, and plasma. J Lab Clin Med. 1957 Jun;49(6):962–974. [PubMed] [Google Scholar]
- SMALL M. D., LONGARINI A. E., ZAMCHECK N. Observations of liver function in chlorpromazine-treated alcoholic patients. N Engl J Med. 1957 May 16;256(20):932–934. doi: 10.1056/NEJM195705162562004. [DOI] [PubMed] [Google Scholar]