Figure 3.

Correlation of potency for rotenoids, flavonoids, and stilbenoids from cubé insecticide as inhibitors of NADH:ubiquinone oxidoreductase and phorbol ester-induced ODC activities. Compounds in each series [rotenone (compounds 1–10), deguelin (compounds 11–29), flavonoid (compounds 30–36 and 38), and stilbenoid (compounds 39–41)] are numbered separately in the order of decreasing potency as inhibitors of NADH:ubiquinone oxidoreductase. Eight rotenoids inactive in both assays (IC₅₀ >10,000 nM) are shown in the upper right box. Compounds with discrete values in one assay but >10,000 nM in the other are arbitrarily plotted as 10,000 in the latter case. Rotenoid IC₅₀ values of >10,000 nM are assigned the value of 10,000 in deriving the correlation coefficient. Correlation coefficients are 0.86 (n = 29) for the rotenoids, 0.98 (n = 11) for the flavonoids and stilbenoids from cubé, and 0.98 (n = 13) for the latter compounds plus genistein (compound 37) and resveratrol (compound 42). The flavonoids and stilbenoids are generally less potent than the rotenoids but fall on the same overall correlation line (composite figure not shown).