Figure 3.

Alignment of the catalytic domain sequences of adamalysin II (ADAM_CROAD) (7) and human ADAM 10 (hADAM10) (23) with TACE (2, 3). These sequences were aligned according to their topological equivalence and visually, respectively. Residue numbering is made according to the coded TACE sequence. Arrows and braces represent β-strands and α-helices in TACE. Blue symbols indicate topologically nonequivalent residues of adamalysin and TACE, and red designates residues that are identical in all three proteinases.