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Schematic view of the protective mechanisms of Stat3 against Fas-mediated liver injury. Activation of Stat3 upregulates caspase-related proteins (such as FLIP, Bcl-XL, and Bcl-2) and redox-related protein Ref-1. These proteins collaboratively prevent Fas-mediated liver injury in redox-dependent and/or independent ways. Mt., mitochondria.
