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. 1968 Aug 17;3(5615):405–407. doi: 10.1136/bmj.3.5615.405

Circadian Rhythm of Plasma 11-Hydroxycorticosteroids in Psychiatric Disorders

R T W L Conroy, B D Hughes, J N Mills
PMCID: PMC1986352  PMID: 5667319

Abstract

Studies of the circadian rhythm in plasma 11-O.H.C.S. levels showed that a subgroup of affective psychotics had higher plasma 11-OHCS values as compared with schizophrenic and other psychotic subgroups, and a somewhat less regular rhythm. One patient with depression who was studied over 48-hour periods showed a reduction in plasma 11-OHCS levels with clinical recovery. An accentuated fall and rise in plasma 11-OHCS values in the night and early morning samples, respectively, was observed in the schizophrenic subgroup.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BLISS E. L., CLARK L. D., WEST C. D. Studies of sleep deprivation-relationship to schizophrenia. AMA Arch Neurol Psychiatry. 1959 Mar;81(3):348–359. doi: 10.1001/archneurpsyc.1959.02340150080009. [DOI] [PubMed] [Google Scholar]
  2. BLISS E. L., SANDBERG A. A., NELSON D. H., EIK-NES K. The normal levels of 17-hydroxycorticosteroids in the peripheral blood of man. J Clin Invest. 1953 Sep;32(9):818–823. doi: 10.1172/JCI102798. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. BOARD F., PERSKY H., HAMBURG D. A. Psychological stress and endocrine functions; blood levels of adrenocortical and thyroid hormones in acutely disturbed patients. Psychosom Med. 1956 Jul-Aug;18(4):324–333. doi: 10.1097/00006842-195607000-00006. [DOI] [PubMed] [Google Scholar]
  4. BOARD F., WADESON R., PERSKY H. Depressive affect and endocrine functions; blood levels of adrenal cortex and thyroid hormones in patients suffering from depressive reactions. AMA Arch Neurol Psychiatry. 1957 Dec;78(6):612–620. [PubMed] [Google Scholar]
  5. Bridges P. K., Jones M. T. The diurnal rhythm of plasma cortisol concentration in depression. Br J Psychiatry. 1966 Dec;112(493):1257–1261. doi: 10.1192/bjp.112.493.1257. [DOI] [PubMed] [Google Scholar]
  6. Conroy R. T., Elliott A. L., Hughes B. D., Mills J. N. Physiological variables in some psychiatric patients. J Physiol. 1968 May;196(2):129P–130P. [PubMed] [Google Scholar]
  7. Doig R. J., Mummery R. V., Willis M. R., Elkes A. Plasma cortisol levels in depression. Br J Psychiatry. 1966 Dec;112(493):1263–1267. doi: 10.1192/bjp.112.493.1263. [DOI] [PubMed] [Google Scholar]
  8. Elithorn A., Bridges P. K., Lobban M. C., Tredre B. E. Observations on some diurnal rhythms in depressive illness. Br Med J. 1966 Dec 31;2(5530):1620–1623. doi: 10.1136/bmj.2.5530.1620. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. GIBBONS J. L. CORTISOL SECRETION RATE IN DEPRESSIVE ILLNESS. Arch Gen Psychiatry. 1964 Jun;10:572–575. doi: 10.1001/archpsyc.1964.01720240026004. [DOI] [PubMed] [Google Scholar]
  10. GIBBONS J. L., McHUGH P. R. Plasma cortisol in depressive illness. J Psychiatr Res. 1962 Sep;1:162–171. doi: 10.1016/0022-3956(62)90006-7. [DOI] [PubMed] [Google Scholar]
  11. HOAGLAND H., PINCUS G., ELMADJIAN F., ROMANOFF L., FREEMAN H., HOPE J., BALLAN J., BERKELEY A., CARLO J. Study of adrenocortical physiology in normal and schizophrenic men. AMA Arch Neurol Psychiatry. 1953 Apr;69(4):470–485. doi: 10.1001/archneurpsyc.1953.02320280058006. [DOI] [PubMed] [Google Scholar]
  12. Hullin R. P., Bailey A. D., McDonald R., Dransfield G. A., Milne H. B. Variations in II-hydroxycorticosteroids in depression and manic-depressive psychosis. Br J Psychiatry. 1967 Jun;113(499):593–600. doi: 10.1192/bjp.113.499.593. [DOI] [PubMed] [Google Scholar]
  13. Knapp M. S., Keane P. M., Wright J. G. Circadian rhythm of plasma 11-hydroxycorticosteroids in depressive illness, congestive heart failure, and Cushing's syndrome. Br Med J. 1967 Apr 1;2(5543):27–30. doi: 10.1136/bmj.2.5543.27. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. LOBBAN M., TREDRE B., ELITHORN A., BRIDGES P. DIURNAL RHYTHMS OF ELECTROLYTE EXCRETION IN DEPRESSIVE ILLNESS. Nature. 1963 Aug 17;199:667–669. doi: 10.1038/199667a0. [DOI] [PubMed] [Google Scholar]
  15. MATTINGLY D. A simple fluorimetric method for the estimation of free 11-hydroxycorticoids in human plasma. J Clin Pathol. 1962 Jul;15:374–379. doi: 10.1136/jcp.15.4.374. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. McClure D. J. The diurnal variation of plasma cortisol levels in depression. J Psychosom Res. 1966 Sep;10(2):189–195. doi: 10.1016/0022-3999(66)90062-6. [DOI] [PubMed] [Google Scholar]
  17. REISS M. Investigations into psychoendocrinology. Int Rec Med Gen Pract Clin. 1953 May;166(5):196–203. [PubMed] [Google Scholar]
  18. Randrup A., Munkvad I. Changes in urine volume and diurnal rhythm caused by reserpine treatment of schizophrenic patients. Br J Psychiatry. 1966 Feb;112(483):173–176. doi: 10.1192/bjp.112.483.173. [DOI] [PubMed] [Google Scholar]
  19. SACHAR E. J., MASON J. W., KOLMER H. S., Jr, ARTISS K. L. PSYCHOENDOCRINE ASPECTS OF ACUTE SCHIZOPHRENIC REACTIONS. Psychosom Med. 1963 Nov-Dec;25:510–537. doi: 10.1097/00006842-196311000-00002. [DOI] [PubMed] [Google Scholar]
  20. SPENCER PEET J., DALY J. R., SMITH V. A SIMPLE METHOD FOR IMPROVING THE SPECIFICITY OF THE FLUORIMETRIC DETERMINATION OF ADRENAL CORTICOSTEROIDS IN HUMAN PLASMA. J Endocrinol. 1965 Feb;31:235–244. doi: 10.1677/joe.0.0310235. [DOI] [PubMed] [Google Scholar]

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