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Magnified view of the T4 DNA polymerase exonuclease active center. Residues D112 and E114 reside within the exonuclease active center. Proposed hydrogen bonds between D131 and Y317 and between D131 and T116 are illustrated. The Y317 and E114 residues are separated by 4 Å and may interact indirectly through an ordered water molecule (J. Wang and T. A. Steitz, personal communication).
