Fig. 1.

Segregation of INS mutations in 16 families. Squares represent male family members, and circles represent female members. Black circles and squares represent persons with diabetes. A slash mark through the square or circle indicates deceased. A slash mark through the branch indicates the couple has divorced. The allele status is indicated under the symbols: N/N, two normal alleles; amino acid change/N, one mutated and one normal allele; N/A, not available for testing. The arrow indicates the proband. Family relationship was confirmed in all families by microsatellite analysis, except in UC2 (parents not available for testing) and UC105.