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Effect of the duration of ischemia on cardiac eNOS activity. Hearts were homogenized at the end of normal perfusion or after different durations of ischemia, and eNOS activity was measured by l-[14C]arginine to l-[14C]citrulline conversion. Loss of NOS activity paralleled the duration of ischemia and was fully restored by BH4 with shorter ischemic times but only partially with longer durations. *, P < 0.001 + BH4 vs. basal eNOS activity, n = 5 hearts per point.
