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. 2007 Sep 10;104(38):15138–15143. doi: 10.1073/pnas.0707171104

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© 2007 by The National Academy of Sciences of the USA

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Fig. 5. — Hypothalamic histopathology in the setting of altered circadian body temperature rhythm. (A) Body temperature data in rhesus monkey 521 (upper trace) and 523 (lower trace) were monitored until a disruption in circadian parameters was observed, at which time, animals were killed. (B–D) Histopathology of the hypothalamus, illustrated in the SPZ. The third ventricle is shown at right, with the ependymal lining visible in B and C. Photomicrographs [original magnification: ×10; ×60 (C Inset and D Inset)] of CD163 immunohistochemistry in control uninfected animal 556 (B) and SIV-infected animals 521 (C) and 523 (D). CD163-reactive ramified microglia (notable in C, region with * shown in C Inset) and macrophages (notable in D, region with * shown in D Inset) are not found in control animals (e.g., B).