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. Author manuscript; available in PMC: 2007 Sep 19.
Published in final edited form as: Curr Neurovasc Res. 2005 Oct;2(4):271–285. doi: 10.2174/156720205774322584

Fig. (8). Nicotinamide (NIC) does not alter anoxia-induced p38 and JNK activation.

Fig. (8)

The effect of NIC on anoxia-induced phosphorylation of p38 (A) and JNK (B) was determined. Total protein extracts were prepared from either untreated control cultures or from cultures 1 h after a 4 h period of anoxia with or without pretreatment with NIC (12.5 mM). The cellular level of total p38 (A) and JNK (B) remained unchanged in each group. A significant expression of active form of p38 (p-p38) and JNK (p-JNK) was detected from cultures exposed to anoxia. Pretreatment with NIC 1 h prior to anoxia did not prevent anoxia-induced the activation of p38 (A) and JNK (B). Data presented are taken from one individual experiment of three giving similar results.