Table 1.
Clinical characteristics of Parkinson's disease patients with Lrrk2 G2019S
| Patient | fPD-225 | sPD-173 | sPD-270 | sPD-283 | sPD-251 |
|---|---|---|---|---|---|
| Mutation (Heterozygous) | G2019S | G2019S | G2019S | G2019S | |
| Mutation (Homozygous) | G2019S | ||||
| Gender | Male | Female | Female | Female | Female |
| Ethnic background | Chilean/Amerindian | Chilean/Amerindian | Chilean/Amerindian | Chilean/Amerindian | Chilean/Amerindian |
| Family history | Yes | No | No | No | No |
| Age-at-onset (year) | 54 | 50 | 73 | 65 | 65 |
| Last examination age (year) | 72 | 69 | 75 | 67 | 77 |
| Disease duration | 18 | 20 | 2 | 4 | 12 |
| L-Dopa response | Yes | Yes | Yes | Yes | Yes |
| Drug induced dyskinesia | Yes | Yes | Yes | Yes | Yes |
| Hoehn and Yahr staging | 3 | 3 | 2 | 3 | 3 |
| UPDRS part III motor | 18 | 15 | 10 | 29 | 25 |
| Typical PD symptoms | Yes | Yes | Yes | Yes | Yes |
| Sign of dementia | No | No | No | No | No |