Table 2.

Chromosome 12q12 haplotype analysis of Chilean Parkinson's disease patients with Lrrk2 G2019S Chromosome 12 genotypes are shown for five Lrrk2 G2019S PD patients. LRRK2 6055 G>A (G2019S) is within exon 41 of the gene. The most parsimonious haplotype associated with disease, consistent with the consensus haplotype previously identified is in the right-hand column in bold. Marker positions (in base pairs) are from the UCSC database (March 2006; http://www.genome.ucsc.edu/). The haplotype is flanked by markers D12S2194 (Chr12q12: 38,738,008b; Allele ‘257’not shared by fPD-225) and D12S1701 (Chr12q12: 46,208,212b; homozygosity lost for sPD-251).

	Marker	Genomic Position	fPD-225	sPD-173	sPD-270	sPD-283	sPD-251 (homozygous)	Consensus sharing
	D12S2194	38,738,008	249/261	257/261	249/257	249/257	257/257
	D12S2514	38,873,791	285/291	291/291	291/297	291/297	291/291	291
ex5	rs10878245	38,918,058	C/C	T/C	T/C	T/C	C/C	C
in t13	rs28903073	38,939,777	G/A	G/A	G/A	G/A	A/A	A
in t30	D12S2516	38,989,235	254/254	254/254	254/254	254/254	254/254	254
in t34	rs11564205	39,000,276	A/G	A/A	A/A	A/A	AA	A
ex41	G2019S	39,020,469	G/A	G/A	G/A	G/A	A/A	A
ex43	rs10878405	39,028,521	A/A	G/A	G/A	G/A	A/A	A
in t43	rs11176143	39,028,630	G/G	G/G	G/G	G/G	G/G	G
in t45	D12S2518	39,034,806	154/154	154/154	154/170	154/170	154/154	154
ex49	rs3761863	39,044,919	C/C	C/C	T/C	T/C	CC	C
	D12S2519	39,116,760	132/140	132/132	132/132	132/132	132/132	132
	D12S2520	39,120,028	260/260	257/260	251/260	251/260	260/260	260
	D12S2521	39,128,575	327/359	359/359	359/367	359/371	359/359	359
	D12S2522	39,132,267	287/297	297/297	297/299	297/299	297/297	297
	D12S2517	39,282,898	192/202	186/192	192/192	190/192	192/192	192
	D12S1048	39,312,654	211/214	211/214	214/223	214/226	214/214	214
	D12S1701	46,208,212	95/101	95/101	95/97	89/95	95/103