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Kinetic parameters of wild-type and selected chimeras with nucleoside analogs.
| ddC | d4T | |||||
|---|---|---|---|---|---|---|
| kcat (s−1) | KM (μM) | kcat/KM (M−1s−1) | kcat (s−1) | KM (μM) | kcat/KM (M−1s−1) | |
| hTK2 | nd | nd | nd | nd | nd | nd |
| DmdNK | 1.5 ± 0.1 | 380 ± 20 | 3.9 × 103 | nd | nd | nd |
| HD-16 | 0.42 ± 0.01 | 1240 ± 110 | 3.4 × 102 | 0.07 ± 0.01 | 66.3 ± 10.3 | 1.1 × 103 |
| HDHD-12 | 1.5 ± 0.1 | 135 ± 11 | 1.1 × 104 | 0.29 ± 0.01 | 148 ± 17 | 1.9 × 103 |
