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. Author manuscript; available in PMC: 2007 Sep 19.
Published in final edited form as: Clin Cancer Res. 2006 Jun 15;12(12):3814–3822. doi: 10.1158/1078-0432.CCR-06-0384

Fig. 6.

Fig. 6

HTLV-1Tax – reactive HTL recognize naturally processed exogenous antigen presented by autologous dendritic cells.The peptideTax191–205-reactive HTL line 9B (A) and peptide Tax305–319-reactive HTL clone 25 (C) were able to recognize the HTLV-1-positive T-cell lymphoma cell lysates (MT2, Hut102) but not HTLV-1-negative JurkatT-cell lymphoma cell lysate presented by autologous dendritic cells. In addition, antigen recognition in all cases was inhibited by anti-DR mAb L243 at 10 μg/mL. The responses of these HTLs to the naturally processed antigen derived from tumor lysate were enhanced by adding HTLV-1Tax – specific mAb Lt-4 at10 μg/mL using tumor lysates from HTLV-1+ MT2 or Hut102 but not HTLV-1-negative Jurkat lysate (B and D). Columns, mean of triplicate determinations; bars, SD. Columns without bars had SD <10% the value of the mean. Representative of two experiments that were done under the same conditions and with the same samples.